Primary cilia in neurodevelopmental disorders
نویسندگان
چکیده
منابع مشابه
Neurodevelopmental Disorders
The effective identification of neurodevelopmental disorders is essential for early diagnosis and provision of intervention services. For many of these conditions, one of the primary domains of abnormality is language development. This review addresses what is known about the earliest indicators of language impairment across a range of neurodevelopmental disorders; consideration is given to bot...
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Copy number variations (CNVs) consist of duplications or deletions of chromosomal regions ranging from a few hundred to more than a million bases in size, and are likely to play a role in phenotypic diversity and evolution. Recent advances in the identification and mapping of CNVs among normal individuals and in model systems, using bioinformatics and hybridization-based methods, are beginning ...
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Human faces exhibit enormous variation. When pathological conditions are superimposed on normal variation, a nearly unbroken series of facial morphologies is produced. When viewed in full, this spectrum ranges from cyclopia and hypotelorism to hypertelorism and facial duplications. Decreased Hedgehog pathway activity causes holoprosencephaly and hypotelorism. Here, we show that excessive Hedgeh...
متن کاملPrimary cilia
The primary cilium was first so named by Sergei Sorokin in 1968.[1] Since the discovery of primary cilium in 1898 by Zimmerman, three major hypotheses for their function have been put forth. The first is that primary cilia are vestigial organelles inherited from an ancestor whose cells had motile cilia and now are of no purpose in multicellular organisms. The second is that they are involved in...
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lization. This independence of calcium and PGE 2 has been reported previously and suggests that there are multiple mechanisms by which bone cells sense their mechanical environment. These findings are currently in press in the Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. by oscillatory fluid flow via intracellular calcium mobilization and activation of ...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2013
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2013.247